Ald-CH2-PEG4-Propargyl, Propargyl-PEG4 Aldehyde
CAS: 1341156-62-4
Description:
Ald-CH2-PEG4-Propargyl is a multifunctional linker with an aldehyde group (Ald), a PEG4 spacer, and a propargyl group. The aldehyde allows conjugation with primary amines, while the propargyl group supports copper-free click chemistry with tetrazine. Additionally, it can form stable oxime conjugates with aminooxy and hydrazide groups, making it highly versatile for bioconjugation and molecular assembly.
Key Features:
- Aldehyde Group: Enables efficient conjugation with primary amines to form stable imine bonds.
- Propargyl Group: Supports strain-promoted click chemistry with tetrazine, enabling selective conjugation in bioorthogonal reactions.
- Aminooxy and Hydrazide Conjugation: Forms stable oxime and hydrazone conjugates, expanding the range of conjugation possibilities.
- PEG4 Spacer: Enhances solubility, flexibility, and biocompatibility, reducing steric hindrance during reactions.
Applications:
- Bioconjugation: Links biomolecules with primary amines, tetrazine, aminooxy, and hydrazide groups for targeted conjugation.
- Drug Delivery Systems: Enables the conjugation of therapeutic molecules for precise, targeted delivery.
- Protein and Antibody Labeling: Ideal for modifying proteins, peptides, or antibodies for imaging and therapeutic applications.
- Molecular Assembly: Useful for constructing complex molecular structures in biochemical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.