Ald-CH2-PEG2-CH2CO2 tBu ester (CAS: 2230956-95-1)
Ald-CH2-PEG2-CH2CO2 tBu ester serves as a bifunctional PEG linker with an aldehyde group (-CHO) and a tert-butyl ester-protected carboxylic acid (-CO₂tBu). The aldehyde group efficiently reacts with hydrazide and aminooxy groups, forming stable covalent bonds. Meanwhile, acidic conditions remove the tert-butyl ester, revealing a free carboxylic acid for further conjugation. Additionally, its PEG₂ spacer increases solubility and minimizes steric hindrance, making it ideal for bioconjugation and drug development applications.
Key Features:
- Functional Groups:
- Aldehyde (-CHO): Reacts efficiently with hydrazide and aminooxy groups, creating strong linkages.
- Tert-Butyl Ester (-CO₂tBu): Protects the carboxyl group and releases a free carboxylic acid upon acid treatment, enabling secondary reactions.
- PEG₂ Spacer:
- Enhances water solubility, ensuring compatibility with aqueous environments.
- Provides molecular flexibility while reducing steric hindrance, improving conjugation efficiency.
Applications:
- Bioconjugation:
- Enables the attachment of biomolecules such as proteins, peptides, and antibodies through selective aldehyde-based coupling reactions.
- Drug Development:
- Functions as a linker in synthesizing antibody-drug conjugates (ADCs) and other therapeutic compounds, improving drug delivery potential.
Handling and Storage:
- Molecular Formula: C₁₀H₁₈O₅
- Molecular Weight: 218.25 g/mol
- Purity: ≥95%
- Storage: Store in a cool, dry place, away from light and moisture to maintain product stability.
Overall, this product supports advanced chemical research by enabling versatile bioconjugation and drug development. Its dual reactive groups and flexible PEG₂ spacer make it an essential tool in pharmaceutical and biochemical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.