Ald-benzyl-PEG5-CH2 tBu-ester
Ald-benzyl-PEG5-CH2 tBu-ester is a high-purity heterobifunctional PEG linker with an aldehyde for oxime/hydrazone ligation and a t-butyl ester–protected acid for orthogonal conjugation. The PEG5 spacer enhances solubility, flexibility, and accessibility, enabling efficient bioconjugation in aqueous and organic systems. The acid-labile t-butyl ester allows controlled deprotection for stepwise functionalization, making it especially ideal for precision linker design in drug delivery, diagnostics, and advanced biomaterials.
Key Features and Benefits
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Aldehyde Group: Enables chemoselective conjugation with aminooxy- or hydrazide-containing molecules.
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t-Butyl Ester Protection: Allows controlled deprotection for sequential functionalization.
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PEG5 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
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Heterobifunctional Design: Supports orthogonal, dual-step conjugation strategies.
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High Purity: Supplied at >95% purity for reliable, reproducible performance.
Applications
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Stepwise bioconjugation for precision linker assembly.
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Protein, peptide, and antibody modification.
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Nanoparticle and surface functionalization.
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Targeted drug delivery systems.
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Development of multifunctional diagnostic probes.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
This product provides aldehyde and protected acid functionalities in a PEG5 spacer for especially versatile, orthogonal bioconjugation in drug delivery, diagnostics, and biomaterials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
