Acid-CH2-PEG5-CH2-t-butyl ester
This heterobifunctional PEG reagent contains a terminal carboxylic acid and a t-Boc-protected ester linked by a PEG5 spacer with –CH2– groups. The PEG chain specifically enhances solubility and flexibility, while the t-butyl ester provides acid-labile protection for controlled deprotection and orthogonal conjugation.
Key Features and Benefits:
-
Carboxylic Acid Group: Enables coupling with amines for bioconjugation and functionalization.
-
t-Butyl Ester Protection: Provides acid-labile protection for selective synthetic steps.
-
PEG5 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
-
High Purity: Ensures reproducible results in research and manufacturing workflows.
-
Versatile Reactivity: Compatible with both aqueous and organic systems.
Applications:
-
Bioconjugation: Coupling of biomolecules via amide bond formation.
-
Drug Delivery: Serves as a PEG linker to enhance pharmacokinetics and solubility.
-
Surface Modification: Functionalization of nanoparticles, hydrogels, or biosensors.
-
Material Science: PEGylation of polymers and advanced materials.
Storage and Handling:
-
Storage: Store at –20 °C, protected from light and moisture.
-
Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain integrity of acid and ester groups.
This product provides controlled protection and flexible PEG spacing, making it useful for orthogonal and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
