Acetic acid, 2,2′-dithiobis-dihydrazide CAS:6854-84-8 is a chemical compound that is commonly used in biochemistry and molecular biology.It is a symmetric compound that contains two hydrazide functional groups and two thiol groups connected by a disulfide bond.
Acetic acid, 2,2′-dithiobis-dihydrazide is a widely used reagent for the quantification of thiol-containing compounds, such as cysteine, glutathione, and proteins. In the presence of a thiol compound, the disulfide bond in Acetic acid, 2,2′-dithiobis-dihydrazide is cleaved, resulting in the formation of a yellow-colored compound called 5-thio-2-nitrobenzoic acid.
Acetic acid, 2,2′-dithiobis-dihydrazide is also used as a reagent for the modification of proteins and peptides. The hydrazide groups in It can react with the carbonyl groups in proteins and peptides to form a hydrazone linkage. This reaction can be used to introduce a thiol-reactive group into a protein or peptide, which can then be used for the attachment of other molecules or for the formation of disulfide bonds between two proteins or peptides.
Acetic acid, 2,2′-dithiobis-dihydrazide is commonly used in the development of assays and probes for the detection of thiol-containing compounds, as well as in the chemical modification of proteins and peptides for various applications.
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