6-Maleimido-1-Hexanal
This product is a heterobifunctional linker containing a maleimide group, a six-carbon spacer, and a terminal aldehyde. The maleimide reacts selectively with thiols to form stable thioether bonds, while the aldehyde couples with amines or hydrazides through Schiff base or hydrazone formation. Its compact hydrophobic chain provides moderate spacing and flexibility, making this reagent especially useful for bioconjugation, protein labeling, and probe development.
Key Features and Benefits
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Maleimide Group: Reacts selectively with thiols to form stable thioether bonds.
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Aldehyde Group: Couples with amines or hydrazides for reversible or stable linkages.
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C6 Spacer: Provides hydrophobic spacing and moderate flexibility.
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Dual Reactivity: Supports orthogonal thiol and aldehyde conjugation strategies.
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High Purity: Produced to ≥95% purity for reproducible performance.
Applications
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Protein Labeling: Links thiol- and amine-containing biomolecules.
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Bioconjugation: Builds multifunctional probes and conjugates.
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Drug Delivery: Serves as a cleavable or modular linker.
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Probe Development: Enables aldehyde-based derivatization for imaging or diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; aldehydes are moisture- and oxidation-sensitive.
This product integrates thiol reactivity with aldehyde functionality in a compact scaffold, specifically providing a versatile reagent for controlled conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
