20-(tert-Butoxy)-20-oxoicosanoic acid
20-(tert-Butoxy)-20-oxoicosanoic acid is a high-purity bifunctional fatty acid derivative with a terminal carboxylic acid for coupling to amines and a tert-butyl ester–protected ω-carboxylic group for orthogonal conjugation. The long C20 alkyl chain provides hydrophobic character, making it ideal for lipid–drug conjugates, hydrophobic anchor design, and biomaterial modification. The acid-labile tert-butyl ester enables especially controlled deprotection for stepwise functionalization in drug delivery, diagnostics, and material science applications.
Key Features and Benefits
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Terminal Carboxylic Acid: Couples efficiently to primary amines via carbodiimide or other activation chemistries.
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t-Butyl Ester Protection: Acid-labile, allowing selective deprotection for sequential conjugation.
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C20 Alkyl Chain: Provides hydrophobicity for membrane association or lipid-based delivery systems.
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Orthogonal Reactivity: Supports stepwise functionalization workflows.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Lipid–Drug Conjugates: Attach payloads to hydrophobic chains for membrane targeting or depot formulations.
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Nanoparticle Surface Modification: Introduce hydrophobic anchors into lipid bilayers or polymeric carriers.
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Biomaterials Engineering: Functionalize hydrophobic scaffolds for tissue engineering or drug release.
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Prodrug Development: Build hydrophobic prodrugs for controlled release.
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Diagnostic Probe Development: Create lipid-linked imaging agents.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DCM or DMF; avoid prolonged exposure to moisture to preserve reactivity.
This product combines a reactive carboxylic acid with a protected ω-acid in a hydrophobic C20 chain, enabling stepwise functionalization specifically for lipid-based drug delivery, biomaterials, and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
