2-(t-Butoxycarbonylamido)-1,3-bis(PFP-oxycarbonylethoxy)propane
This product is a heterobifunctional crosslinking reagent containing a Boc-protected amide and two pentafluorophenyl (PFP) carbonate groups connected via an ether-propane backbone. The Boc group offers acid-labile protection for controlled deprotection, while the PFP esters provide highly reactive, hydrolytically stable handles for efficient amine coupling.
Key Features and Benefits:
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Dual PFP Carbonates: Highly reactive toward primary amines for stable conjugation.
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Boc-Protected Amide: Acid-labile group for orthogonal and stepwise synthesis.
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Propane Backbone: Provides a compact, defined spacer for crosslinking.
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High Purity: Suitable for reproducible bioconjugation and synthetic workflows.
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Stable and Versatile: PFP esters offer greater hydrolytic stability than NHS esters.
Applications:
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Bioconjugation: Crosslink proteins, peptides, or biomolecules via amine reactivity.
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Drug Delivery Systems: Acts as a linker for attaching payloads or functional groups.
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Surface Functionalization: Introduces stable amine-reactive sites on nanoparticles or polymers.
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Synthetic Chemistry: Useful intermediate for orthogonal conjugation strategies.
Storage and Handling:
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Storage: Store at –20 °C, dry and protected from light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain PFP ester reactivity.
This reagent combines dual PFP esters with a Boc-protected amide, making it an especially versatile crosslinker for stepwise and orthogonal conjugation in advanced bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.