1-(3-Hydroxypropyl)-1H-pyrrole-2,5-dione
This product is a high-purity N-substituted maleimide featuring a terminal hydroxyl group for further functionalization. The maleimide moiety enables selective thiol coupling via Michael addition under mild conditions, making it especially ideal for bioconjugation, polymer modification, and surface functionalization.
Key Features and Benefits
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Maleimide Group – Reacts selectively with thiol groups for stable thioether bond formation
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Hydroxyl Group – Serves as a versatile handle for further chemical modification
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Mild Reactivity – Thiol–maleimide coupling proceeds efficiently under physiological conditions
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High Purity – >95% purity ensures reliable and reproducible performance
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Versatile Use – Suitable for both aqueous and organic systems
Applications
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Protein and peptide thiol labeling
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Antibody–drug conjugate (ADC) synthesis
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Hydrogel and polymer functionalization
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Nanoparticle surface modification
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Custom linker synthesis
Storage and Handling
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Store at –20 °C, dry, and protected from light
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Use anhydrous solvents such as DMSO or DMF for dissolution
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Avoid prolonged exposure to moisture to prevent hydrolysis
This product is a functional maleimide linker with a hydroxyl group specifically for derivatization, enabling selective thiol coupling and versatile bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
