Amino-PEG4-t-butyl ester
This product is a heterobifunctional PEG linker containing a primary amine, a PEG4 spacer, and a tert-butyl ester. The amine couples efficiently with carboxyls or activated esters to form stable amides, while the tert-butyl ester protects a carboxyl group for orthogonal deprotection. The PEG4 chain improves solubility and reduces steric hindrance, making this reagent especially versatile for bioconjugation, probe design, and drug delivery.
Key Features and Benefits
-
Amine Group: Couples with carboxyls or NHS esters to form amides.
-
t-Butyl Ester: Provides a protected carboxyl for controlled deprotection.
-
PEG4 Spacer: Enhances solubility, flexibility, and accessibility.
-
Orthogonal Reactivity: Enables stepwise or dual functionalization strategies.
-
High Purity: Produced to ≥95% purity for consistent performance.
Applications
-
Bioconjugation: Links biomolecules with amine and protected carboxyl groups.
-
Protein and Antibody Labeling: Provides controlled orthogonal modification.
-
Drug Delivery: Serves as a modular PEG linker in therapeutics.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, desiccated container.
-
Handling: Remove t-butyl ester under mild acidic conditions; prepare fresh solutions.
This product combines a reactive amine, a protected ester, and PEG solubility in a medium-length scaffold, specifically offering versatility for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
