2′-OMe-A(Bz) Phosphoramidite

2′-OMe-A(Bz) Phosphoramidite, CAS 110782-31-5, is a reliable reagent for synthesizing 2′-O-methyl RNA oligonucleotides. The 2′-O-methyl modification enhances stability and resists nuclease degradation. As a result, it is ideal for therapeutic, diagnostic, and research applications.

Key Features
The 2′-O-methyl modification adds stability, protecting oligonucleotides from degradation by nucleases. This keeps them intact in biological environments for longer periods.
Meanwhile, benzoyl (Bz) protection ensures a clean and efficient synthesis process, leading to high yields and pure oligonucleotides.
Additionally, the enhanced hybridization improves binding to complementary strands, giving you more precise results in therapeutic and diagnostic uses.

Applications

• Oligonucleotide Synthesis: Perfect for creating stable 2′-O-methyl RNA oligonucleotides used in research and medical studies.
• Therapeutics: Ideal for developing antisense oligonucleotides and RNA therapies because of its strong resistance to nucleases.
• Diagnostic Probes: Creates stable and highly specific molecular probes, making diagnostic assays more accurate.
• RNA Interference (RNAi): Great for gene silencing and RNAi studies where stability and efficiency are crucial.

Benefits
The high stability provided by the 2′-O-methyl modification keeps oligonucleotides intact, making them more effective in applications.
It also allows for precise hybridization, which improves the accuracy of binding to target sequences—critical for diagnostics and therapeutic applications.
Moreover, the high purity synthesis process, thanks to benzoyl protection, minimizes unwanted side reactions, resulting in cleaner and more reliable oligonucleotides.

In short, with 2′-OMe-A(Bz) Phosphoramidite, you get enhanced stability, precise binding, and high purity, making it a top choice for your oligonucleotide synthesis projects.