Amine-PEG-t-Butyl ester, MW 5K is a versatile compound used in various fields, including pharmaceutical research and development. This compound is composed of three essential functional groups: an amine group, a polyethylene glycol (PEG) chain, and a t-Butyl ester group. The amine group (-NH2) confers basic properties to the compound, while the PEG chain (-OCH2CH2-) imparts hydrophilicity, solubility, and biocompatibility. The t-Butyl ester group (-COO-t-Bu) provides steric hindrance and protects the amine group from unwanted reactions.
In pharmaceutical research and development, Amine-PEG-t-Butyl ester is commonly used as a building block for the synthesis of drug delivery systems, bioconjugates, and prodrugs. Due to its hydrophilic and biocompatible PEG chain, Amine-PEG-t-Butyl ester can increase the solubility, stability, and half-life of drugs, as well as reduce their toxicity and immunogenicity. the amine group in Amine-PEG-t-Butyl ester, MW 5K can be used to conjugate drugs or targeting ligands, such as antibodies or peptides, to improve their specificity and efficacy. The t-Butyl ester group can also be selectively cleaved by enzymes or acids in the target site, releasing the active drug or ligand.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.