Acrylate-PEG-Maleimide (ACRL-PEG-MAL), MW 10K is a crosslinker with a PEG spacer. Maleimides can react with thiol-containing groups. Acrylates can be polymerized with UV light or free radical initiators.
Acrylate-PEG-Maleimide,MW 10K belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains both acrylate and maleimide functional groups.
The acrylate group (-COOCH=CH2) is known for its ability to undergo free radical polymerization, making Acrylate-PEG-Maleimide a useful precursor for the synthesis of hydrogels and other polymeric materials. Additionally, the maleimide group (-CO-NH-CH=CH2) is highly reactive towards thiol groups, enabling the covalent attachment of thiol-containing molecules, such as peptides and proteins, to the PEG chain.
Acrylate-PEG-Maleimide,MW 10K has been widely used in the development of advanced drug delivery systems, such as antibody-drug conjugates (ADCs) and targeted nanocarriers. Its unique chemical properties allow for the site-specific conjugation of therapeutic agents, such as chemotherapeutic drugs, to the maleimide-functionalized PEG chain. The resulting conjugates exhibit improved stability, increased solubility, and enhanced targeting efficacy, leading to improved therapeutic outcomes and reduced side effects.
Furthermore, APM has also been employed in the fabrication of biomaterials and tissue engineering scaffolds, where its ability to form hydrogels and its biocompatibility make it a valuable tool for the design and optimization of novel biomedical devices.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
