The high-purity Amino-PEG4-MMAE provided by Axispharm can be coupled with amine groups through PEG linkers to synthesize antitumor agents. MMAE is a synthetic antineoplastic agent. It can attach to monoclonal antibodies (MABs), directing them to cancer cells. Amino groups react with carboxylic acids, activated NHS esters, carbonyl groups (ketones, aldehydes), etc. Hydrophilic PEG spacers increase solubility in aqueous media.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.