t-Boc-N-amido-PEG10-azide is a specialized, bifunctional polyethylene glycol (PEG) derivative featuring a tert-butyloxycarbonyl (t-Boc) protected amine group at one end and an azide moiety at the other. This unique combination of functional groups enables its use in various applications within pharmaceutical research and development, particularly in the field of bioconjugation.
The t-Boc group safeguards the amine functionality during synthesis, allowing for selective deprotection when required. The azide group, on the other hand, facilitates click chemistry reactions, such as copper-catalyzed azide-alkyne cycloaddition (CuAAC), which are known for their high efficiency, selectivity, and biocompatibility. These properties make t-Boc-N-amido-PEG10-azide an invaluable tool for the synthesis of peptide- or protein-based therapeutics, targeted drug delivery systems, and biomolecule conjugates. The PEG10 spacer enhances the solubility, stability, and bioavailability of the resulting conjugates, ultimately improving their pharmacokinetic and pharmacodynamic profiles.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
