Thalidomide-5-(PEG2-amine) is a proteolytic targeting chimera (PROTAC) building block containing an E3 ligase ligand substituted with a terminal amine group. Amine groups can react with NHS ester groups or carboxylic acids in the presence of EDC or HATU. Prepare to bind target protein ligands to form PROTACs containing 5′-substituted thalidomide as the cereblon ligand.
Thalidomide-5-(PEG2-amine) is a synthetic molecule composed of thalidomide and a polyethylene glycol (PEG) group. It is used in research for its anti-inflammatory and anti-angiogenic properties, and has potential applications in the treatment of various diseases such as cancer, Crohn’s disease, and Alzheimer’s disease.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.