Ald-CH2-PEG5-azide CAS:2566404-73-5 provided by axispharm is a degradable ADC linker that can synthesize antibody drugs (ADC). It is a cross-linking agent containing azide and aldehyde groups. The reaction reacts with alkyne, DBCO and BCN moieties. Aldehyde groups react with amines and the N-terminus of peptides and proteins to form imines containing a C=N double bond, which can be further reduced. PEG aldehyde or ketone derivatives can be used for reversible PEGylation by their reaction with hydrazine or hydrazide to form hydrolyzed acylhydrazone bonds. This reagent is for research use only.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
