Phthalimidine, 2-(2,6-dioxopiperiden-3-yl), (CAS: 26581-81-7)
Phthalimidine, 2-(2,6-dioxopiperiden-3-yl) serves as a valuable lenalidomide analog in PROTAC synthesis. It combines a phthalimide structure with a 2,6-dioxopiperidine moiety, making it effective for binding cereblon (CRBN), an E3 ubiquitin ligase. This binding capability is crucial for creating PROTACs that target specific proteins for degradation.
Key Features:
- Lenalidomide Analog: Mimics lenalidomide, binding to CRBN for targeted protein degradation.
- PROTAC Synthesis: Acts as a building block for designing PROTACs with high degradation efficiency.
- Reactive Sites: The phthalimide and dioxopiperidine enable easy chemical modifications.
Applications:
- PROTAC Development: Creates chimeric molecules that guide CRBN to degrade target proteins.
- Drug Discovery: Supports research focused on new therapies for undruggable protein targets.
- Organic Synthesis: Helps build complex molecular structures for advanced chemical research.
Advantages:
- Strong CRBN Binding: Efficiently engages CRBN, enhancing the effectiveness of PROTACs.
- Versatile Use: Facilitates various synthetic routes for customized degradation compounds.
- Effective in Targeted Degradation: Plays a central role in modern medicinal chemistry strategies.
Phthalimidine, 2-(2,6-dioxopiperiden-3-yl) is ideal for PROTAC development, drug discovery, and medicinal chemistry. It offers a straightforward approach to creating innovative protein degradation therapies.
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