D-Amino-PEG6-Thalidomide TFA Salt
This product is a heterobifunctional linker combining a thalidomide moiety, a six-unit PEG spacer, and a D-amino handle in trifluoroacetate salt form. The thalidomide unit binds cereblon (CRBN), specifically enabling use in PROTAC and molecular glue design. The D-amino group provides orthogonal conjugation chemistry, while the PEG6 spacer enhances solubility and accessibility for bioconjugation and drug discovery.
Key Features and Benefits
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Thalidomide Moiety: Binds CRBN E3 ligase for targeted protein degradation.
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D-Amino Group: Provides reactivity for conjugation with activated esters or carboxyls.
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PEG6 Spacer: Improves solubility and reduces steric hindrance.
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TFA Salt Form: Enhances stability and handling.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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PROTAC Development: Links warheads to thalidomide for targeted degradation.
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Bioconjugation: Couples biomolecules through the D-amino handle.
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Probe Development: Builds CRBN-recruiting probes for mechanistic studies.
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Medicinal Chemistry: Serves as a versatile building block in drug discovery.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Dissolve freshly before use; protect from moisture and light.
This product combines CRBN binding, D-amino reactivity, and PEG solubility in a stable salt form, making it especially ideal for targeted degradation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.