N-Boc-N-bis(PEG4-NHS ester)
This product is a multifunctional crosslinker featuring a Boc-protected amine core and two PEG4–NHS ester arms. The NHS esters specifically react efficiently with primary amines to form stable amide bonds. The Boc group provides orthogonal protection, allowing controlled deprotection for further functionalization, while the PEG4 spacers improve solubility and reduce steric hindrance.
Key Features and Benefits
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Dual NHS Esters: Couple efficiently with amines for reliable crosslinking.
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Boc-Protected Amine: Provides orthogonal functionality for stepwise modification.
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PEG4 Spacers: Enhance solubility and flexibility while minimizing steric effects.
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Multifunctional Design: Enables sequential or dual conjugation strategies.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Protein Crosslinking: Links two amine-containing biomolecules with PEG spacing.
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Bioconjugation: Supports multifunctional labeling strategies.
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Drug Delivery: Serves as a modular cleavable linker for therapeutics.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Remove Boc under mild acidic conditions; prepare NHS ester solutions fresh to avoid hydrolysis.
This product combines orthogonal Boc protection with dual NHS ester reactivity, specifically offering flexibility for controlled crosslinking and conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
