m-PEG6-SS-PEG6-methyl
This product is a cleavable, symmetrical PEG linker containing two six-unit PEG chains connected by a disulfide bond and capped with a methyl group. The disulfide enables reductive cleavage under intracellular or reducing conditions, while the PEG6 arms improve solubility and flexibility. This reagent is especially valuable for designing cleavable PEGylated conjugates, drug delivery systems, and bioconjugation workflows.
Key Features and Benefits
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Disulfide Bond: Cleaves under reducing conditions for controlled release.
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Symmetrical PEG6 Arms: Provide solubility, flexibility, and spacing.
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Methyl Capping: Prevents undesired crosslinking.
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Cleavable Design: Enables reversible PEGylation strategies.
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High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
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Drug Delivery: Creates cleavable PEGylated therapeutics with controlled release.
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Bioconjugation: Links molecules with reversible PEG protection.
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Probe Development: Builds cleavable probes for imaging and diagnostics.
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Nanotechnology: Stabilizes nanoparticles with reducible PEG coatings.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product combines reversible disulfide cleavage with PEG6 solubility, specifically offering a versatile tool for cleavable conjugation and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
