Acid-PEG2-SS-PEG2-acid
This product is a cleavable PEG linker with two terminal carboxyl groups, dual PEG2 spacers, and a central disulfide bond. The carboxyls couple with amines or NHS esters to form stable amides, while the disulfide enables reductive cleavage for controlled release. The short PEG2 chains improve solubility and flexibility, making this reagent especially useful for bioconjugation, drug delivery, and probe design.
Key Features and Benefits
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Carboxyl Groups: Enable amide bond formation with amines.
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Disulfide Bond: Provides cleavability under reducing conditions.
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PEG2 Spacers: Improve solubility and reduce steric hindrance.
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Bifunctional Design: Supports symmetric conjugation strategies.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Drug Delivery: Builds cleavable linkers for controlled therapeutic release.
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Bioconjugation: Links biomolecules with reversible disulfide chemistry.
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ADC Development: Serves as a cleavable spacer in antibody–drug conjugates.
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Probe Design: Creates reducible probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; avoid prolonged exposure to reducing agents.
This product integrates cleavable disulfide chemistry with dual carboxyl reactivity in a compact PEG scaffold, making it especially versatile for controlled conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
