TCO-PEG2-TCO CAS:2411687-18-6 is a bifunctional PEG-based linker, featuring two terminal trans-cyclooctene (TCO) groups connected by a polyethylene glycol (PEG) spacer with a molecular weight of approximately 2000 Da. This unique structure enables high water solubility, biocompatibility, and enhanced pharmacokinetic profiles, making it an ideal choice for advanced bioconjugation applications.
In pharmaceutical research and development, TCO-PEG2-TCO is extensively utilized as a bioorthogonal, chemoselective linker for conjugating biomolecules such as proteins, antibodies, and small-molecule drugs. It plays a pivotal role in the design of antibody-drug conjugates (ADCs), targeted drug delivery systems, and novel therapeutics, significantly improving the efficacy and specificity of treatments while minimizing off-target effects and toxicity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
