TCO-PEG2-amine CAS:2141981-87-3 is a high-quality bioconjugation reagent widely utilized in pharmaceutical research and development. Comprising a trans-cyclooctene (TCO) moiety, a polyethylene glycol (PEG) spacer, and a primary amine functional group, this innovative compound provides excellent versatility in bioorthogonal chemistry applications.
The TCO moiety enables rapid and selective reactions with tetrazine-functionalized molecules through inverse electron-demand Diels-Alder (IEDDA) cycloaddition. The PEG2 spacer imparts enhanced solubility and reduces steric hindrance, while the amine group allows for straightforward conjugation to various biomolecules, including proteins, antibodies, and small molecules.
TCO-PEG2-amine has found extensive application in pharmaceutical R&D, including the development of targeted drug delivery systems, antibody-drug conjugates, and bioconjugate-based diagnostics. The rapid and selective nature of TCO-tetrazine reactions allows for efficient conjugation in complex biological environments, while the PEG spacer improves pharmacokinetic properties and reduces immunogenicity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
