How Linker Design Drives the Success of Antibody-Drug Conjugates (ADCs)
In the early stages of ADC development, researchers often overlooked linker design, thinking that adding...
18
Nov
PEG & ADC
24
Oct
Comparison of Label-Free Protein Quantification in Saliva: Fusion Lumos vs. TimsTOF Pro2
Comparison of Label-Free Protein Quantification in Saliva: Fusion Lumos vs. TimsTOF Pro2
This comparison of Fusion Lumos a...
23
Oct
From Design to Degradation: The Essential Role of Linkers in PROTACs
PROTAC (Proteolysis Targeting Chimera) technology is revolutionizing drug development by targeting disease-causing proteins d...
17
Oct
What are Degrader Antibody Conjugates (DACs): How PROTACs are Transforming Targeted Therapy
What are Degrader Antibody Conjugates (DACs): How PROTAC PEGs are Transforming Targeted Therapy
Degrader Antibody Conjugates (DACs) ar...
17
Oct
Targeting Cancer: Discover the Power of Folate Receptor Chimeras (FRTAC) for Selective Degradation
Mechanism of Action
Folate Receptor Chimeras (FRTACs) are designed to leverage the strong binding of folate receptors (FRs) to folate c...
08
Oct
How Bispecific Antibodies Like MCLA-158 are Changing Cancer Treatment with ADCs
A bispecific antibody (BsAb) is a type of engineered antibody that can bind two different antigens or epitopes simultaneously. With...
03
Oct
Comprehensive List of FDA-Approved Antibody-Drug Conjugates (ADCs) – Updated for 2024
Comprehensive List of FDA-Approved Antibody-Drug Conjugates (ADCs) – Updated for 2024
Overview:
Antibody-Drug Conjuga...
01
Oct
PEG Lipids: Enhancing Drug Delivery and Therapeutic Efficacy
What Are PEG Lipids?
PEG lipids, or PEGylated lipids, peg conjugated lipidsare polyethylene glycol (P...
25
Sep
Oxime and Hydrazone Reactions in Bioconjugation [with Top 10 most Asked Questions About Oxime and Hydrazone Reactions]
Oxime and Hydrazone Reactions: Essential Tools in Bioconjugation
Introduction
Oxime and hydrazone reactions are widely used in biocon...
24
Sep
Mastering Maleimide Reactions in Bioconjugation: Your Ultimate Hands-On Guide
Overview
The maleimide reaction, particularly the thiol-maleimide reaction, is a cornerstone of bioconjugation, commonly used ...
24
Sep
PEG Linkers Explained: Types, Uses, and Why They Matter in Bioconjugation
PEG Linkers: Versatile Tools for Bioconjugation and Drug Delivery
PEG (Polyethylene Glycol) linkers are essential components in the fi...
18
Sep
Comprehensive Statistical Analysis of Phosphoramidites: Market Trends, Applications, and Innovations
Interactive Table of Contents
17
Sep
12 most commonly asked questions about phosphoramidites
Commonly Asked Questions About Phosphoramidites
1. What are phosphoramidites used for?
Phosphoramidites are the building blocks for...
10
Sep
Comprehensive Guide for Surface Modification Protocols with Chemical Linkers
Comprehensive Surface Modification Protocols with Chemical Linkers
Surface modification with chemical linkers i...
03
Sep
PDC: A Complement to ADC or a New Frontier?
Exploring new types of drugs is a continuous endeavor in the pharmaceutical industry. After small molecules consi...
27
Aug
Ultimate Guide to Choosing the Right Biotin PEG Linker
Introduction
Biotin PEG linkers are essential tools in biochemical research and biotechnology for conjugating biotin to proteins, pe...
19
Aug
Ultimate Guide to Choosing the Right Cleavable Linker for ADCs
Antibody-drug conjugates (ADCs) are sophisticated therapeutic agents designed to target and kill cancer cells while minimizing damage t...
04
Aug
Understanding ADCs: An Introduction to Targets
ADC (Antibody-Drug Conjugates) are targeted drugs composed of antibodies, linkers, and cytotoxic drugs. They use ...
11
Jul
Unlocking the Power of AOCs: How Antibody-Oligonucleotide Conjugates Are Shaping the Future of Precision Medicine
The Rise of Antibody-Oligonucleotide Conjugates (AOCs)
In the past decade, Antibody-Drug Conjugates (ADCs) have...
02
Jul
An Introduction to Linkers in Antibody-Drug Conjugates (ADCs)
Antibody-drug conjugates (ADCs) are “biological bullets” that combine cytotoxic drugs (payloads) with antibodies ...
27
Jun
ADC Drugs Already Marketed Globally: Compilation of Technical Reviews
ADC (Antibody Drug Conjugate) is a complex that connects cytotoxic drugs to monoclonal antibodies targeting tumor...
17
Jun
A Comprehensive Introduction to Bispecific ADCs
Antibody-drug conjugates (ADCs) consist of an antibody, a linker, and a cytotoxic payload. Compared to traditiona...
10
Jun
ADC Conjugation Technologies
This article introduces conjugation technologies based on carbonyl, amide, azido, and other amino acid funct...
06
Jun
Advances in ADC Linker Research
Due to improvements in payloads, linkers, and conjugation methods, antibody-drug conjugates (ADCs) have seen sign...
29
May
Cleavable Linkers Play a Pivotal Role in the Success of Antibody-Drug Conjugates (ADCs)
Cleavable linkers used in ADC development can release drugs under specific conditions, such as changes in pH, th...
22
May
Next-Generation of Novel Antibody-Drug Conjugates: Click Chemistry ADCs
Currently, ADCs used in clinical settings mostly rely on effective internalization and transport to intracellular...
20
May
The High Hydrophilicity of ADC Linker Has Become the Main Trend in Modification
Founded in 2018, ProfoundBio originated in Seattle, Washington, USA. The three core founders are Dr. Baiteng Zhao...
13
May
Analysis of Multiple Factors Influencing ADC Pharmacokinetics
Antibody-drug conjugates (ADCs) are complex molecules wherein monoclonal antibodies are linked to cytotoxic drugs...
08
May
What is BCN：A Versatile Bioconjugation Tool
The BCN moiety is a strained cyclooctyne, which can react selectively with azide groups to form a stable triazole...
05
May
Challenges in Antibody-Drug Conjugate (ADC) Development
The next generation of ADCs employs enhanced strategies to achieve optimal stability and specificity, thereby imp...
27
Apr
ADC: All You Need to Know About Targeting, Termination, Optimization, and Phase II/III Clinical Trials
After decades of development, ADC drugs have entered a mature stage, with 15 ADCs approved globally and several A...
23
Apr
XDC | Various New Drug Conjugates, In Addition to ADC, There Are More Choices.
With the continuous development of technology, the boundaries of drug conjugates are constantly expanding. Throug...
01
Apr
ADC to XDC, Five Major Elements of Antibody Conjugate Drugs, Exploring the Fundamental Source of Innovation
From ADC to XDC, the future trend of conjugated drugs will focus on new target antigens, payloads with new mechan...
17
Mar
Click Chemistry: The Go-To Toolkit for Fast and Efficient Reactions
Click Chemistry: The Go-To Toolkit for Fast and Efficient Reactions
What is Click Chemistry?
Click chemistry is ...
25
Jan
What is BiotinylationProtein？
Chemical Methods of Protein Biotinylation
Protein biotinylation, a vita...
25
Sep
What are Ionizable Lipids?
Ionizable Lipids Overview
Ionizable lipids are lipid molecules that stay neutral at normal physiological pH but...
25
Sep
What are Cationic Lipids?
Cationic lipids belong to a group of lipid molecules characterized by a permanently positively charged head group...
28
Jun
Polyethylene Glycol Classification
The Ultimate Guide to Polyethylene Glycol (PEG): Classification, Properties, and Applications
Polyethylene Glyc...
20
Jun
Solid Lipid Nanoparticles (SLNs)
Solid lipid nanoparticles (SLNs) have emerged as a promising drug delivery system due to their various advantage...
19
Jun
In Vitro vs In Vivo Studies of Polyethylene Glycol (PEG) Linkers
Polyethylene glycol (PEG) molecules have been used extensively as linkers in drug development, mainly due to thei...
22
May
Why Human epidermal growth factor receptor 2 (HER2) is an attractive target for ADC
HER2 (Human Epidermal Growth Factor Receptor 2) is a protein that ...
10
Feb
What is the difference between ADC linker and PEG linker?
Linkers are molecules used to connect two different molecules together to form a larger, more complex structure. They are used in many ...
09
Feb
Application of PEG Linker
A PEG (polyethylene glycol) linker is a chemical compound that is used to connect two or more molecules together. PEG is a water-solubl...
14
Nov
What is biotinylation?
Biotinylation: Techniques and Applications
Introduction
Biotinylation is the process of attaching biotin to proteins, pep...
11
Nov
What are the ingredients of a COVID-19 vaccine?
What is an mRNA vaccine? Like other types of vaccines, mRNA vaccines work by activating our own immune response, so that our bodies pro...
10
Nov
The Importance of Polyethylene Glycol (PEG) to the Pharmaceutical Industry
Polyethylene glycol (PEG) is a safe, inactive, and nontoxic polymer that is commonly used for molecular modification. Therapeutic benef...
09
Nov
Technical characteristics of PROTAC technology in drug research and development
Most of the drugs currently in clinical use are based on small molecules and use an "occupancy-driven" mode of action to inhibit the fu...
08
Nov
What is SPDP Crosslinker?
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive grou...
05
Nov
Difference Between Polymer PEG (Polydisperse PEG) and Monodisperse PEG
The polymer PEG is a polyethylene glycol (PEG) polymer, a polyether compound derived from petroleum that has many applications ranging ...
04
Nov
What is polyethylene glycol (PEG) modification?
Polyethylene glycol (PEG) modification is a polyethylene glycol with functional groups, which is mainly used for protein drug modificat...
28
Oct
What are ADC Linkers?
Antibody-drug conjugates (ADCs) are the most popular chemoimmunotherapy agents in recent years. ADCs can enhance the ability to target ...
18
Oct
The list of PEGylated drugs approved by FDA Up to 2024
Polyethylene glycol (PEG) is a polymer material that is widely used for covalent modification of biopolymers such as proteins and pepti...
30
Sep
What is polyethylene?
Overview
Polyethylene (PE) is a versatile thermoplastic resin made by polymerizing ethylene, often with small amounts of alpha-olefi...
27
Sep
GLP-1 receptor agonist Drug list and mechanism of action
Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of drugs commonly used for the treatment of type 2 diabetes and, more rec...
28
Aug
Stem cells successfully repair refractory type 1 diabetes
With the improvement of people's living standard, the incidence of diabetes is increasing day by day. This poses ...
27
Aug
ADC drug for urothelial carcinoma( effective rate 81.6%)
Urothelial carcinoma (UC) is a common type of bladder cancer, accounting for approximately 90% of all bladder can...
18
Aug
Can changing your diet help fight cancer?
An article published on «Nature» stated that diet can adjust insulin levels and improve the anticancer effect of ...
13
Aug
Scientists Develop Magical Nanoparticles For Treat The Brain Cancer
In recent years, due to the development of medical technology, scientists continue to explore new ways to treat c...
22
Jul
How Structure and Ligand-Based Drug Design Shape Modern Drug Discovery
In modern drug discovery, two main approaches are widely used: Structure-Based Drug Design (SBDD) and Ligand-Bas...
08
Jul
What are the most important things to pay attention to during the preparation of antibody-conjugated drugs?
Antibody conjugated drugs are formed by linking monoclonal antibodies targeting specific antigens and small molec...
30
Jun
New type of cancer immunotherapy: only kills cancer cells, not healthy cells accidentally
In 2018, two pioneers in cancer immunotherapy won the Nobel Prize in Physiology or Medicine. This newly pioneered...
26
Jun
ADC Linkers And Research Progress In Detail
ADC linkers are not only the molecular parts that form covalent connections between antibodies and small molecula...
23
Jun
Key Points To Realize The Anti-cancer Potential Of ADC Drugs
The past decade has been a decade of accumulation and harvest for ADC. After the second new ADC drug Adcetris (Br...
09
Jun
Esophageal cancer activates the ancient virus hidden in the human genome and also provides new targets for cancer treatment
According to the latest global cancer burden data released by the International Agency for Research on Cancer of ...
09
Jun
Acellular Extracellular Matrix Bio-ink Build Tissue And Organ-Specific Microenvironment
Tissue engineering is a revolutionary strategy to rebuild new organs or tissues through the use of various biomed...
09
Jun
PEG solution therapy in treating acute hepatic encephalopathy
Scientists from Baylor University Medical Center pointed out, the common drugs used to clean the patient’s intest...
09
Jun
ADCs Enfortumab Vedotin Receives Accelerated FDA Approval
Urothelial cancer accounts for more than 90% of bladder cancer. Patients diagnosed with metastatic disease have a...
09
Jun
Dendrimer targeted therapy for cancer
In view of the local invasiveness and remote metastasis characteristics of malignant tumors, the treatment effec...
09
Jun
Cell therapy of vitamin-lipid nanoparticles to treat sepsis
Sepsis is an organ dysfunction caused by the host's abnormal immune response to infection. Sepsis affects millions of people worldwid...
09
Jun
New drug for multiple sclerosis! FDA approval of PLEGRIDY (peginterferon beta-1a)
Biogen recently announced that the U.S. Food and Drug Administration (FDA) has approved Plegridy (pegylated inte...
09
Jun
Folate receptor crystal structure-anti-cancer drug development
Folic acid and vitamin B9 is an essential substance for cell growth. Indiana University scientists have revealed...
09
Jun
Cleavable & Non- Cleavable Linkers with Antibody-Drug Conjugates
Antibody-drug conjugates (ADC) have been identified as the main treatment therapy for clinical cancer treatment. The principle of ADC i...
09
Jun
The Rise Of 3D Cell Printing Technology
What if scientists no longer rely on scarce organ donations, but can build healthy new organs quickly and cheapl...
09
Jun
PEG Polypeptides Chemical Modification
A polypeptide is a compound formed by multiple amino acids connected by peptide bonds. They are ubiquitous in org...
09
Jun
Types of anti-tumor prodrugs that exist
Prodrugs is a compound through enzyme or nonenzymatic action in the body to release active matter. It has less ac...
09
Jun
Have you used these common labeling tools?
The antibody or protein labeling refers to covalently linking a target substance (enzyme, fluorescein, biotin) to an antibody or ot...
08
Jun
FDA Approves Biogen’s New Alzheimer’s Drug Aducanumab
On June 7, the US FDA announced the approval of Biogen/Eisai's Aβ (amyloid β) antibody Aduhelm (aducanumab) for t...
29
May
Monoclonal Antibody-drug Stability Optimization
Monoclonal Antibody-Drug Stability Optimization
Monoclonal antibody drugs are essential in biopharmaceuticals, ...
26
May
Photoimmune ADC: A New Frontier in Targeted Cancer Therapy
Photoimmune ADCs represent an innovative type of antibody-drug conjugate (ADC) that combines targeted antibodi...
20
May
New Cancer Materials, Nano-Gold Cancer Treatments
The history of human struggle with cancer is very long, from surgery, radiotherapy, and chemotherapy, to immunot...
06
May
Unlocking the Future: How GPCR-Targeted ADCs Are Changing Cancer Therapy
G protein-coupled receptors (GPCRs) are crucial membrane proteins involved in cellular signaling and various dise...
24
Apr
Growth factor PEG-fibronectin hydrogel
Extracellular matrix-derived matrigel contains a variety of growth factors. And it has ECM properties that suppor...
14
Apr
Tisotumab vedotin, a new drug for cervical cancer ADC will apply for marketing!
Cervical cancer originates from the cells of the cervix. The disease is still one of the leading causes of cancer...
06
Apr
HER2, the first ADC drug for HER2-positive gastric cancer, approved in Japan
Abstract
Daiichi Sankyo recently announced that Japan’s Ministry of Hea...
29
Mar
What is a fluorescent probe?
Fluorescence is a luminescence phenomenon of photoluminescence. When certain substances are excited by light, ele...
22
Mar
Polyethylene Glycol Modification Reagent in Protein Medicine
Modified PEG is also called modified polyethylene glycol, which is a PEG-modified by a chemical modification grou...
16
Mar
What is cancer? How should we prevent it?
Cancer refers to malignant tumors originating from epithelial tissues and is the most common type of malignant t...
12
Mar
What is ADC(Antibody-drug Conjugates)?
Abstract
ADCs combine the high specificity of monoclonal a...
10
Mar
What is PEG/PEG-linker？
Polyethylene glycol(PEG) is an ethylene glycol polymer with a relative molecular weight of 200 to 8000 or more t...