In Vivo DMPK Analysis Services by AxisPharm

In vivo DMPK (Drug Metabolism and Pharmacokinetics) analyzes how drugs behave in living organisms. AxisPharm offers expert DMPK analysis in species including mice, rats, dogs, monkeys, cats, rabbits, and guinea pigs. Our services provide crucial insights into absorption, distribution, metabolism, and excretion (ADME), supporting drug development, regulatory submissions, and formulation optimization.

AxisPharm’s Key In Vivo DMPK Servicesin vivo DMPK (Drug Metabolism and Pharmacokinetics) services-AxisPharm

  1. Single Dose PK
    • Measures how a drug is absorbed, distributed, metabolized, and excreted after a single dose.
  2. Dose Proportionality (Ascending Dose)
    • Evaluates how drug exposure changes with increasing doses, helping determine safe and effective dosing.
  3. Dose Linearity (Multiple Dose)
    • Assesses the relationship between dose and drug exposure over multiple doses for predictable pharmacokinetics.
  4. Cassette PK (I.V.)
    • Simultaneously evaluates multiple compounds intravenously, streamlining the drug selection process.
  5. Blood-Brain Barrier Permeability
    • Tests a drug’s ability to cross the blood-brain barrier, crucial for CNS-targeted therapies.
  6. Tissue Distribution
    • Measures how a drug spreads across different tissues, revealing target engagement and off-target effects.
  7. Mass Balance
    • Tracks the drug’s fate by quantifying its recovery from biological samples, providing a complete ADME profile.
  8. Toxicokinetics
    • Links drug exposure levels with observed toxic effects to assess safety margins.
  9. PK Formulation Screening and Optimization
    • Compares formulations to identify the best option for enhanced bioavailability and therapeutic effect.

Applications of In Vivo DMPK

  • Drug Development: Supports drug optimization, dosing strategies, and safety assessments.
  • Regulatory Submissions: Provides essential pharmacokinetic data for FDA and EMA compliance.
  • Bioavailability Studies: Determines the fraction of drug reaching systemic circulation.
  • Drug-Drug Interaction: Identifies potential interactions that could impact efficacy or safety.

Advanced Techniques Used

  • LC-MS/MS: For precise measurement of drugs and metabolites in biological matrices.
  • Microdialysis: Monitors drug concentrations in tissues, providing real-time data.
  • Radiolabeling: Tracks the ADME of radiolabeled drugs for detailed analysis.

Why Choose AxisPharm?

  • Diverse Species Expertise: We work with multiple animal models to fit your study needs.
  • Comprehensive Analysis: We provide full ADME profiles that guide drug development decisions.
  • Customized Studies: Tailor-made studies ensure relevant and high-quality data.
  • Quality Results: Rigorous quality control ensures reliable, reproducible data.

Partner with AxisPharm for In Vivo DMPK

AxisPharm delivers precise, detailed in vivo DMPK analysis to support drug development from early research to clinical trials. Our expert team and advanced technologies provide the data you need to make informed decisions. Contact us today to discuss your in vivo DMPK needs.