When the compound enters the body, it will be distributed in various organs along with the blood circulation. Since different organs have different physiological structures and internal physical and chemical properties (such as pH, etc.), the compounds are unevenly distributed in various organs. By measuring the drug concentration of the compound in various organs in the body and studying the distribution of drugs to specific tissues in the animal body, it is helpful to choose the indication of the compound, and it can also help to understand the toxicological problems that may occur in the later period of the compound development.
At AxisPharm, we use non-radioactive methods to study the distribution of drugs to specific tissues in rats and mice.
Drug Tissue Distribution Analysis
| Species | Mouse, rat |
| Dosing route | P.O., I.V., I.M.; I. P. etc |
| Groups | multiple groups, one group per time point |
| Dosage | TBD |
| Dosing frequency | Single dose or repeat dose |
| Number of animals | 3 per group |
| Time points | TBD |
| Tissue Analyzed | Heart, liver, spleen, lung, kidney, gallbladder, small intestine, large intestine, brain, reproductive system, bone marrow, pancreas, muscle, fat, etc. |
| Analysis method | LC-MS/MS |
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