Ion Chromatography – HPIC

High Performance Ion Chromatography (HPIC) Services

Ion Chromatography (IC) is a powerful analytical technique used to identify the molecular composition of materials, playing a vital role in pharmaceuticals, environmental quality analysis, and contaminant detection across various industries. High Performance Ion Chromatography (HPIC) takes this process further, offering a fast, simple, and accurate method for analyzing contaminants. Used widely across environmental, industrial, biological, pharmaceutical, chemical, and food sectors, HPIC supports applications from quality control to environmental monitoring.

Advantages of Ion Chromatography

IC is highly versatile, known for its sensitivity, selectivity, speed, and accuracy. It detects both organic acids and inorganic ionic contaminants such as chlorine, sulfates, phosphates, and ammonia. These residues, often left behind during manufacturing, can cause product failures if not properly managed.

Ion Chromatography Applications

Quality Control & Product Cleanliness

IC ensures product quality, safety, and functionality by detecting ionic contaminants in manufacturing. It’s particularly valuable in sectors like medical devices, electronics, and hard drives. For instance, an electronics manufacturer experiencing electrical shorts in circuit boards used IC to identify hard-water residues, allowing them to resolve the issue by changing the rinse water.

Environmental Analysis and Water Analysis

HPIC is a key tool for environmental monitoring, water testing for pollutants and contaminants. Manufacturers also use IC to check rinse water for potential contaminants, ensuring clean production processes.

Additives Identification in Food and Beverages 

With growing consumer concerns about additives, IC is used to analyze and quantify additives in food, beverages, and other consumer products, ensuring compliance and safety.

Pharmaceuticals and Drug Development

Added to the United States Pharmacopoeia-National Formulary (USP-NF) in 2006, IC is essential in the pharmaceutical industry. It measures residual limits of substances like oxalate, iodide, sulfate, and electrolytes. IC also assesses the stability and solubility of APIs, dissolution profiles of tablets and capsules, and detects excipients like sugars, alcohols, and impurities.

HPIC Capacity at AxisPharm

AxisPharm offers advanced HPIC services with the capacity to detect:

• Trace ionic species (F-, Br-, Cl-, NO2-, NO3-, HPO4-2, SO4-2)
• Trace cations (Li+, Na+, K+, Mg+2, Ca+2, Sr+2, Ba+)
• Ammonium and low molecular weight amines
• Quaternary ammonium compounds
• Oxyhalides and weak organic acids
• Silicates, aliphatic and aromatic sulfonic acids
• Amino acids and custom HPIC analysis tailored to your needs

Contact US

Reach out to our skilled analysts to discuss your specific IC analysis needs. Let AxisPharm’s HPIC services support your quality control, environmental testing, and product development goals.