Metabolomics Services: Unveiling the Secrets of Your Biological System
AxisPharm’s Metabolomics Services provide comprehensive analysis of metabolites—small molecules that reveal critical insights into physiological and biochemical processes. By examining the metabolome, we offer a detailed snapshot of the metabolic state of cells, tissues, or organisms, aiding in disease research, drug development, and more.
What is Metabolomics?
Metabolomics is the study of small molecules, or metabolites, that are the end products of cellular processes. Unlike gene expression or protein analysis, which offer indirect insights, metabolomics provides a direct “functional readout” of the physiological state of a biological system.
Why Metabolomics?
- Comprehensive Insight: Metabolomics captures an immediate snapshot of physiological and pathological states, offering direct insight into cellular function.
- Quantifiable Correlations: Metabolomics can correlate with other omics data (genome, transcriptome, proteome, lipidome) to predict metabolite levels and enhance systems biology understanding.
- Advantages Over Other Omics:
- Ease of Detection: Amplifies small changes in gene and protein expression.
- Database Support: Utilizes extensive compound libraries without the need for extensive genomic databases.
- Generic Techniques: Metabolite detection is universally applicable across different tissues.
- Direct Results: Reflects physiological and pathological states, distinguishing phenotypic differences.
Metabolomics Analysis Approaches
- Untargeted Metabolomics
- Description: Identifies and quantifies a broad range of metabolites without prior knowledge of which metabolites are present.
- Applications: Discovery of new biomarkers and pathways.
- Targeted Metabolomics
- Description: Focuses on quantifying specific metabolites known to be relevant to the study.
- Applications: Verification of biomarker levels and metabolic pathway analysis.
Analytical Technologies Used
- Gas Chromatography-Mass Spectrometry (GC-MS): Ideal for analyzing water-soluble metabolites, lipids, and organic acids.
- Liquid Chromatography-Mass Spectrometry (LC-MS): Used for both targeted and untargeted analyses of small molecules, including amino acids, carbohydrates, and lipids.
- Nuclear Magnetic Resonance (NMR) Spectroscopy: Provides substance identification and analysis of purified samples.
Our Metabolomics Process
- Sample Collection & Preparation
- Sources: Blood, urine, plasma, cells, tissues, etc.
- Preparation: Extraction, internal standards, and derivatization.
- Analysis
- Techniques: LC-MS, GC-MS, NMR for separation, identification, and quantification of metabolites.
- Data Processing
- Features: Metabolite feature extraction, statistical analysis (e.g., PCA), bioinformatics for disease associations and metabolic signatures.
Applications of Metabolomics
- Biomedical Research: Metabolomic profiling for biomarker discovery and understanding disease mechanisms.
- Pharmaceuticals: Drug metabolism and toxicity studies.
- Clinical Settings: Disease diagnosis, treatment monitoring, and personalized medicine.
- Agriculture & Food Industry: Plant metabolomics, pesticide development, and food quality analysis.
Why Choose AxisPharm for Metabolomics?
- Comprehensive Coverage: Analyzing a wide range of metabolites from small molecules to large lipids.
- Advanced Technology: Equipped with state-of-the-art MS, GC-MS, LC-MS, and NMR instruments.
- Expertise: Experienced team in metabolomics analysis, bioinformatics, and statistics.
- Custom Solutions: Tailored analysis and reporting to fit specific research needs and applications.
Get Started with AxisPharm Metabolomics Services
Contact Us for detailed information or to request a quote. Our team is ready to help you achieve your research goals with precise and insightful metabolomics analysis.
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