Inductively Coupled Plasma Mass Spectrometry (ICP-MS) is a powerful analytical technique used for detecting trace elements and quantifying metals and non-metals at extremely low concentrations, down to parts per trillion (ppt). This technology is widely employed across various industries, including environmental monitoring, geochemical analysis, metallurgy, pharmaceuticals, and clinical research.

Key Concepts of ICP-MS

  1. What is ICP-MS?

    • ICP-MS stands for Inductively Coupled Plasma Mass Spectrometry, an elemental analysis technique that combines a high-temperature plasma source with a mass spectrometer. The plasma source ionizes the sample, and the mass spectrometer detects and quantifies the ions based on their mass-to-charge ratios.

  2. How Does ICP-MS Work?

    • ICP-MS Analysis involves several key steps:
      1. Sample Introduction: A sample, usually in liquid form, is introduced into the plasma through a nebulizer.
      2. Ionization: The sample is ionized in the plasma, reaching temperatures of 6,000 to 10,000 K, which effectively breaks down the sample into its constituent ions.
      3. Mass Spectrometry: The ions are then directed into a mass spectrometer, which separates them based on their mass-to-charge ratios, allowing for precise quantification of trace elements.

  3. Applications of ICP-MS:

    • Environmental Monitoring: Detection of trace metals in water, soil, and air samples to ensure compliance with regulatory standards.
    • Geochemical Analysis: Analysis of rock, soil, and mineral compositions for mining and exploration.
    • Metallurgy: Characterization of metals and alloys to assess purity and contamination.
    • Pharmaceutical Analysis: Quality control and validation of drug formulations by detecting trace elements.
    • Clinical Research: Analysis of trace metals in biological fluids, tissues, and other clinical samples.

  4. ICP-MS vs. Other Techniques:

    • Compared to other analytical techniques like Graphite Furnace Atomic Absorption Spectroscopy (GFAAS), ICP-MS offers faster sample processing, higher sensitivity, and the ability to simultaneously detect multiple elements.

Key Instruments and Technologies

  • ICP-MS Spectrometer: The spectrometer is the heart of the ICP-MS system, responsible for the accurate detection of ions. Modern ICP-MS spectrometers are equipped with advanced detectors, collision/reaction cells, and other enhancements that improve sensitivity and reduce interference.

  • MOF ICP-MS (Metal-Organic Framework ICP-MS): MOF materials are sometimes used in sample preparation to pre-concentrate and selectively capture trace elements before analysis, enhancing detection limits and specificity.

  • The Perkin Elmer Sciex ELAN 9000 ICP-MS:

    • This instrument is designed for routine ultra-trace analysis and is known for its robustness and high throughput. It simplifies complex analyses with fast sample turnaround times, providing a performance advantage over traditional methods like GFAAS.

ICP-MS at AxisPharm

At AxisPharm, we provide accurate trace metal analysis services using advanced ICP-MS. Our team utilizes various sample prep techniques, ensuring precise results with fast turnaround times. Whether for research, quality control, or regulatory compliance, we deliver reliable data to meet your needs.

Advantages of ICP-MS

  • High Sensitivity: Detects elements at extremely low levels.
  • Fast Analysis: Simultaneously measures multiple elements, speeding up results.
  • Versatility: Handles diverse sample types—liquids, solids, and gases.

Other Instrumentations From AxisPharm Laboratories:

Gas Chromatography Mass Spectrometry
Ion Chromatography
Liquid Chromatography Mass Spectrometry
Maldi-TOF
Orbitrap
Q-TOF-LC-MS and TQ-LC-MS
Titrations