Azido-PEG12-Hydrazide contains an azide group and a terminal hydrazide group. The hydrophilic PEG spacer can increase solubility of a compound in aqueous media. The azide group readily reacts with alkyne, BCN, DBCO through Click Chemistry to yield a stable triazole linkag. The hydrazide group can be reacted with an aldehyde or ketone to form a hydrozone bond that are reversible under acidic conditions. The reversibility of spacer has been widely utilized to for payload traffiking and release.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.